Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz.

Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz.

Major histocompatibility complex (MHC) class I molecules determine immune responses to viral infections. These polymorphic cell-surface glycoproteins bind peptide antigens, forming ligands for cytotoxic T and natural killer cell receptors. Under pressure from rapidly evolving viruses, hominoid MHC c...

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Bibliographic Details
Main Authors: Emily E Wroblewski, Paul J Norman, Lisbeth A Guethlein, Rebecca S Rudicell, Miguel A Ramirez, Yingying Li, Beatrice H Hahn, Anne E Pusey, Peter Parham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4447270?pdf=render

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http://europepmc.org/articles/PMC4447270?pdf=render

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