Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role

Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role

Background: In the current study, we evaluated the therapeutic potential of sinapic acid (SA) in terms of the mechanism underlying its gastroprotective action against ethanol-induced gastric ulcers in rats.Methods: These effects were examined through gross macroscopic evaluation of the stomach cavit...

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Bibliographic Details
Main Authors: Mohammad Raish, Mudassar Shahid, Yousef A. Bin Jardan, Mushtaq Ahmad Ansari, Khalid M. Alkharfy, Abdul Ahad, Ibrahim Abdelsalam Abdelrahman, Ajaz Ahmad, Fahad I. Al-Jenoobi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
sinapic acid
ethanol
oxidat ive stress
inflammation
Nrf2/HO-1 signaling pathway
gastric mucosal lesions
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.622815/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.622815/full

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