Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase

In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of the hyperthermophilic archaeon Sulfolobus sol...

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Bibliographic Details
Main Authors: Li Phing Liew, Zun Yi Lim, Matan Cohen, Ziqing Kong, Lisette Marjavaara, Andrei Chabes, Stephen D. Bell
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
DNA replication
replication fork
archaea
hydroxyurea
Sulfolobus
DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314279

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716314279

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