Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

The interaction between a GPCR, such as the vasopressin receptor-2 (V2R), and arrestin depends on the receptors’ phosphorylation pattern. Here authors use FRET and NMR to analyze the phosphorylation patterns of the V2R-arrestin complex and show that phospho-interactions are the key determinants of s...

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Bibliographic Details
Main Authors: Qing-Tao He, Peng Xiao, Shen-Ming Huang, Ying-Li Jia, Zhong-Liang Zhu, Jing-Yu Lin, Fan Yang, Xiao-Na Tao, Ru-Jia Zhao, Feng-Yuan Gao, Xiao-Gang Niu, Kun-Hong Xiao, Jiangyun Wang, Changwen Jin, Jin-Peng Sun, Xiao Yu
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22731-x

Internet

https://doi.org/10.1038/s41467-021-22731-x

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