TLR9 ligand (CpG oligodeoxynucleotide) induces CLL B-cells to differentiate into CD20+ antibody-secreting cells

TLR9 ligand (CpG oligodeoxynucleotide) induces CLL B-cells to differentiate into CD20+ antibody-secreting cells

B-cell chronic lymphocytic leukemia (CLL) is the most frequent adult leukemia in the Western world. It is a heterogeneous disease characterized by clonal proliferation and the accumulation of CD5+ mature B lymphocytes. However, the normal counterpart from which the latter cells arise has not yet bee...

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Bibliographic Details
Main Authors: Hussein eGhamlouch, Hakim eOuled-Haddou, Aude eGuyart, Aline eRegnier, Stéphanie eTrudel, Jean-Francois eClaisse, Vincent eFuentes, Bruno eRoyer, Jean-Pierre eMarolleau, Brigitte eGubler
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Immunology
Subjects:
Plasma Cells
memory B cell
CD20
B cell differentiation
chronic lymphocytic leukemia
CpG oligodeoxynucleotide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00292/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00292/full

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