DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells

Abstract Background AT-rich interactive domain-containing protein 1A (ARID1A) is a subunit of the mammary SWI/SNF chromatin remodeling complex and a tumor suppressor protein. The loss of ARID1A been observed in several types of human cancers and associated with poor patient prognosis. Previously, we...

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Bibliographic Details
Main Authors: Zhou-hua Jiang, Tao Peng, Hai-long Qian, Cai-de Lu, Feng Qiu, Su-zhan Zhang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cancer Cell International
Subjects:
ARID1A
β-TRCP
Phosphodegron
DNA damage
Online Access:http://link.springer.com/article/10.1186/s12935-019-0878-y

Internet

http://link.springer.com/article/10.1186/s12935-019-0878-y

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