Engineering regulatory networks for complex phenotypes in E. coli

Regulatory networks respond to environmental and genetic perturbations by reprogramming metabolism. Here the authors screen a library of 82 regulators with 110,120 mutations to map the regulatory network of 4000 genes.

Bibliographic Details
Main Authors: Rongming Liu, Liya Liang, Emily F. Freed, Alaksh Choudhury, Carrie A. Eckert, Ryan T. Gill
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17721-4