A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer

A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer

The next breakthrough for protein therapeutics is effective intracellular delivery and accumulation within target cells. Nuclear localization signal (NLS)-tagged therapeutics have been hindered by the lack of efficient nuclear localization due to endosome entrapment. Although development of strategi...

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Bibliographic Details
Main Authors: Vincent Lacasse, Simon Beaudoin, Steve Jean, Jeffrey V. Leyton
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
antibody-drug conjugates
nuclear localization signal
T-DM1
importins
proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301820

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http://www.sciencedirect.com/science/article/pii/S2329050120301820

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