Mitochondria, Cognitive Impairment, and Alzheimer's Disease

To date, the beta amyloid (Aβ) cascade hypothesis remains the main pathogenetic model of Alzheimer's disease (AD), but its role in the majority of sporadic AD cases is unclear. The “mitochondrial cascade hypothesis” could explain many of the biochemical, genetic, and pathological features of sp...

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Bibliographic Details
Main Authors: M. Mancuso, V. Calsolaro, D. Orsucci, C. Carlesi, A. Choub, S. Piazza, G. Siciliano
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.4061/2009/951548