Blockade of Inflammation and Apoptosis Pathways by siRNA Prolongs Cold Preservation Time and Protects Donor Hearts in a Porcine Model

Blockade of Inflammation and Apoptosis Pathways by siRNA Prolongs Cold Preservation Time and Protects Donor Hearts in a Porcine Model

In donor hearts from mini pigs, overtime cold preservation and ischemia-reperfusion injury cause poor graft quality and impaired heart function. Blockage of complement, apoptosis, and inflammation is considered a strategy for attenuating ischemia-reperfusion injury and protecting cardiac function. M...

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Bibliographic Details
Main Authors: Jia Wei, Shiyou Chen, Song Xue, Qiangru Zhu, Sha Liu, Li Cui, Xiuguo Hua, Yongyi Wang
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
ischemia
reperfusion
small interfering RNA
heart transplantation
porcine model
working heart model
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302846

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http://www.sciencedirect.com/science/article/pii/S2162253117302846

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