Kilohertz frequency deep brain stimulation is ineffective at regularizing the firing of model thalamic neurons

Deep brain stimulation (DBS) is an established therapy for movement disorders, including tremor, dystonia, and Parkinson’s disease, but the mechanisms of action are not well understood. Symptom suppression by DBS typically requires stimulation frequencies ≥ 100 Hz, but when the frequency is increase...

Full description

Bibliographic Details
Main Authors: Joao eCouto, Warren M Grill
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Computational Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncom.2016.00022/full