Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling

Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling

Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term. For effective lysis of their targets, NK cells use a specific cell-...

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Bibliographic Details
Main Authors: Hannah Wurzer, Liza Filali, Céline Hoffmann, Max Krecke, Andrea Michela Biolato, Jérôme Mastio, Sigrid De Wilde, Jean Hugues François, Anne Largeot, Guy Berchem, Jérôme Paggetti, Etienne Moussay, Clément Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
actin cytoskeleton
Cdc42
immune evasion
immunological synapse
tumor immunology
natural killer (NK)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.619069/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.619069/full

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