Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice

Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice

Butyrylcholinesterase (BChE) efficiently hydrolyzes acetylcholine (ACh) at high concentrations when acetylcholinesterase (AChE) is substrate-inhibited. Recent studies have shown that BChE also has a function that is independent of ACh, but it has not been fully explored. Low BChE expression is accom...

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Bibliographic Details
Main Authors: Si Chen, Zhengdong Lin, Kai-Leng Tan, Risheng Chen, Wenfang Su, Haishan Zhao, Qiwen Tan, Wen Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Psychiatry
Subjects:
butyrylcholinesterase
acetylcholine
hippocampus CA1
posttraumatic stress disorder
contextual fear memory
astrocyte
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.564843/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2020.564843/full

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