GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells

GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells

Abstract Background The Hedgehog (Hh) signaling pathway plays critical roles in modulating embryogenesis and maintaining tissue homeostasis, with glioma-associated oncogene (GLI) transcription factors being the main mediators. Aberrant activation of this pathway is associated with various human mali...

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Bibliographic Details
Main Authors: Dengliang Huang, Yiting Wang, Linlin Xu, Limin Chen, Minzhang Cheng, Wei Shi, Huanting Xiong, Detina Zalli, Shiwen Luo
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hedgehog signaling
GLI
ARHGEF16
Glioma
Migration
Proliferation
Online Access:http://link.springer.com/article/10.1186/s13046-018-0917-x

Internet

http://link.springer.com/article/10.1186/s13046-018-0917-x

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