STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1

STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1

Abstract Background The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both in vitro and in vivo studies have revealed that either biochemical or genetic manipulation of the STAT3 pathway activity induce changes in the same direction in Akt activity. However, the im...

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Bibliographic Details
Main Authors: María Elisa Picco, María Victoria Castro, María Josefina Quezada, Gastón Barbero, María Belén Villanueva, Natalia Brenda Fernández, Hyungsoo Kim, Pablo Lopez-Bergami
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cell & Bioscience
Subjects:
STAT3
PDK1
Akt
PKC
SGK
Melanoma
Online Access:http://link.springer.com/article/10.1186/s13578-018-0265-8

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http://link.springer.com/article/10.1186/s13578-018-0265-8

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