Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase

Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase

Amyloid-beta (Aβ) is a critical etiological factor for late-onset familial Alzheimer’s disease (AD). However, an early-onset AD has been found to be related with an Aβ mutation in glutamic acid 22-to-lysine (Italian type E22K). Why only one single point mutation at E22 residue induces AD remains unc...

Full description

Bibliographic Details
Main Authors: Wenjing Jiang, null YanYu, Dandan Yao, Xuechao Fei, Li Ai, Yalan Di, Jingnan Zhang, Xiangpei Yue, Shengjie Zhao, Rongqiao He, Jihui Lyu, Zhiqian Tong
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/4981204

Internet

http://dx.doi.org/10.1155/2020/4981204

Similar Items