Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Although this is a rational approach, previous resea...

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Bibliographic Details
Main Authors: Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4462581?pdf=render

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http://europepmc.org/articles/PMC4462581?pdf=render

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