Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

Abstract Background Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Clinical and experimental studies of Nutlin-3 showed...

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Bibliographic Details
Main Authors: Ulyana Boyarskikh, Sergey Pintus, Nikita Mandrik, Daria Stelmashenko, Ilya Kiselev, Ivan Evshin, Ruslan Sharipov, Philip Stegmaier, Fedor Kolpakov, Maxim Filipenko, Alexander Kel
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Medical Genomics
Subjects:
Lung cancer cell lines
Sensitivity to anticancer drugs
Nutlin-3
p53
Transcription factors
TRANSFAC
Online Access:http://link.springer.com/article/10.1186/s12920-018-0330-5

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http://link.springer.com/article/10.1186/s12920-018-0330-5

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