Stiffer Matrix Accelerates Migration of Hepatocellular Carcinoma Cells through Enhanced Aerobic Glycolysis Via the MAPK-YAP Signaling

Stiffer Matrix Accelerates Migration of Hepatocellular Carcinoma Cells through Enhanced Aerobic Glycolysis Via the MAPK-YAP Signaling

Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells are two fundamental mediators of tumor progression, including hepatocellular carcinoma (HCC). Yet, the correlation between ECM stiffness and excessive aerobic glycolysis in promoting the development of HCC rem...

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Bibliographic Details
Main Authors: Qiu-Ping Liu, Qing Luo, Bin Deng, Yang Ju, Guan-Bin Song
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
hepatocellular carcinoma
ecm stiffness
migration
aerobic glycolysis
mechanotransduction
Online Access:https://www.mdpi.com/2072-6694/12/2/490

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https://www.mdpi.com/2072-6694/12/2/490

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