N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis

N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis

Abstract Background NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactive oxygen species (ROS) in the sterile inflammatory response triggered b...

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Bibliographic Details
Main Authors: Fenglian He, Guanghui Zheng, Jingying Hou, Qiaohua Hu, Qin Ling, Gongfa Wu, Hui Zhao, Jin Yang, Yue Wang, Longyuan Jiang, Wanchun Tang, Zhengfei Yang
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Inflammation
Subjects:
N-acetylcysteine
Cardiopulmonary resuscitation
Myocardial function
Pyroptosis
Online Access:http://link.springer.com/article/10.1186/s12950-020-00255-3

Internet

http://link.springer.com/article/10.1186/s12950-020-00255-3

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