Intestinal Transcytosis of a Protein Cargo and Nanoparticles Mediated by a Non-Toxic Form of <i>Pseudomonas aeruginosa</i> Exotoxin A

Intestinal Transcytosis of a Protein Cargo and Nanoparticles Mediated by a Non-Toxic Form of <i>Pseudomonas aeruginosa</i> Exotoxin A

The low permeability of nanoparticles (NPs) across the intestinal epithelium remains a major challenge for their application of delivering macromolecular therapeutic agents via the oral route. Previous studies have demonstrated the epithelial transcytosis capacity of a non-toxic version of <i>...

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Bibliographic Details
Main Authors: Ruiying Li, Floriane Laurent, Alistair Taverner, Julia Mackay, Paul A. De Bank, Randall J. Mrsny
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
oral protein delivery
in vivo model
transcytosis
nanoparticle
Online Access:https://www.mdpi.com/1999-4923/13/8/1171

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https://www.mdpi.com/1999-4923/13/8/1171

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