Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

The kinase Bub1 functions in the spindle assembly checkpoint (SAC) and in chromosome congression, but the role of its catalytic activity remains controversial. Here, we use two novel Bub1 inhibitors, BAY-320 and BAY-524, to demonstrate potent Bub1 kinase inhibition both in vitro and in intact cells....

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Bibliographic Details
Main Authors: Anna P Baron, Conrad von Schubert, Fabien Cubizolles, Gerhard Siemeister, Marion Hitchcock, Anne Mengel, Jens Schröder, Amaury Fernández-Montalván, Franz von Nussbaum, Dominik Mumberg, Erich A Nigg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
budding uninhibited by benzimidazoles 1
chemical inhibitor
chromosome arm cohesion
spindle assembly checkpoint
chromosome segregation
paclitaxel
Online Access:https://elifesciences.org/articles/12187

Internet

https://elifesciences.org/articles/12187

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