Dendrogenin a Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia

Dendrogenin a Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia

Dendrogenin A (DDA), a mammalian cholesterol metabolite with tumor suppressor properties, has recently been shown to exhibit strong anti-leukemic activity in acute myeloid leukemia (AML) cells by triggering lethal autophagy. Here, we demonstrated that DDA synergistically enhanced the toxicity of ant...

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Bibliographic Details
Main Authors: Pierre-Luc Mouchel, Nizar Serhan, Rémy Betous, Thomas Farge, Estelle Saland, Philippe De Medina, Jean-Sébastien Hoffmann, Jean-Emmanuel Sarry, Marc Poirot, Sandrine Silvente-Poirot, Christian Récher
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
AML
LXR
dendrogenin A
DDA
anthracycline
synergy
Online Access:https://www.mdpi.com/2072-6694/12/10/2933

Internet

https://www.mdpi.com/2072-6694/12/10/2933

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