Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing of FMR1 gene expression leads to the developm...

Full description

Bibliographic Details
Main Authors: Roman Smidak, Fernando J. Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D. Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Fragile X syndrome
Fragile X mental retardation protein
brain aging
dentate gyrus
proteomics
RNA-binding protein
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00384/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00384/full

Similar Items