Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis

Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis

Background & Aims: Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes. We examined the role of TGR5 in alcohol-induced liver injur...

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Bibliographic Details
Main Authors: Madeleine Spatz, Dragos Ciocan, Gregory Merlen, Dominique Rainteau, Lydie Humbert, Neuza Gomes-Rochette, Cindy Hugot, Nicolas Trainel, Françoise Mercier-Nomé, Séverine Domenichini, Virginie Puchois, Laura Wrzosek, Gladys Ferrere, Thierry Tordjmann, Gabriel Perlemuter, Anne-Marie Cassard
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:JHEP Reports
Subjects:
Alcoholic liver disease
Dysbiosis
Kupffer cells
Inflammation
Bile acid
Gut-liver axis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000069

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http://www.sciencedirect.com/science/article/pii/S2589555921000069

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