Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors

Abnormal phosphorylation of tau has been considered as a key pathogenic mechanism inducing tau aggregation in multiple neurodegenerative disorders, collectively called tauopathies. Recent evidence showed that tau phosphorylation sites are protected with O-linked β-N-acetylglucosamine (O-GlcNAc) in n...

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Bibliographic Details
Main Authors: Sungsu Lim, Md. Mamunul Haque, Ghilsoo Nam, Nayeon Ryoo, Hyewhon Rhim, Yun Kyung Kim
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
tau protein
O-GlcNAcylation
O-GlcNAc transferase
O-GlcNAcase
tau phosphorylation
tau aggregation
Online Access:http://www.mdpi.com/1422-0067/16/9/20212

Internet

http://www.mdpi.com/1422-0067/16/9/20212

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