Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer’s Disease

Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer’s Disease

Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline are still unclear. Here we combine genome-wide transcri...

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Bibliographic Details
Main Authors: Wencheng Yin, Navei Cerda-Hernández, Atahualpa Castillo-Morales, Mayra L. Ruiz-Tejada-Segura, Jimena Monzón-Sandoval, Perla Moreno-Castilla, Rodrigo Pérez-Ortega, Federico Bermudez-Rattoni, Araxi O. Urrutia, Humberto Gutiérrez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
beta amyloid deposits
transcriptome
memory decline
neurodegeneration
Alzheimer’s
dementia
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.602642/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.602642/full

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