Lipopolysaccharide and palmitic acid synergistically induced MCP-1 production via MAPK-meditated TLR4 signaling pathway in RAW264.7 cells

Lipopolysaccharide and palmitic acid synergistically induced MCP-1 production via MAPK-meditated TLR4 signaling pathway in RAW264.7 cells

Abstract Background Obesity increases the risk of developing diabetes mellitus. Clinical studies suggest that risk factors like palmitic acid (PA) and lipopolysaccharide (LPS) exist simultaneously in diabetes with obesity. Combination of PA and LPS even at low concentration can induce strong inflamm...

Full description

Bibliographic Details
Main Authors: Xuehong Wang, Xin Jiang, Bin Deng, Juan Xiao, Junfei Jin, Zhaoquan Huang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Lipids in Health and Disease
Subjects:
Palmitic acid
Lipopolysaccharide
MCP-1
MAPK
TLR4
Online Access:http://link.springer.com/article/10.1186/s12944-019-1017-4

Internet

http://link.springer.com/article/10.1186/s12944-019-1017-4

Similar Items