GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma

GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma

G protein-coupled receptor kinase 6 (GRK6) is expressed in various tissues and is involved in the development of several diseases including lung cancer. We previously reported that GRK6 is down-regulated in lung adenocarcinoma patients, which induces cell invasion and metastasis. However, further un...

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Bibliographic Details
Main Authors: Sumei Yao, Ayse Ertay, Yilu Zhou, Liudi Yao, Charlotte Hill, Jinliang Chen, Yangbo Guan, Hui Sun, Rob M. Ewing, Yifei Liu, Xuedong Lv, Yihua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
GRK6
HIF
lung adenocarcinoma
hypoxia
EMT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.654812/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.654812/full

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