Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and targeting the ATG4B protease has been suggeste...

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Bibliographic Details
Main Authors: Niccolo Pengo, Krisna Prak, Joana R. Costa, Christin Luft, Alexander Agrotis, Jamie Freeman, Christina A. Gewinner, A. W. Edith Chan, David L. Selwood, Janos Kriston-Vizi, Robin Ketteler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ATG4B
siRNA
small molecule
kinase
phosphatase
cDNA
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00148/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2018.00148/full

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