Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice
There has been growing awareness of the correlation between an episode of traumatic brain injury (TBI) and the development of Alzheimer’s disease (AD) later in life. It has been reported that TBI accelerated amyloid-β (Aβ) pathology and cognitive decline in the several lines of AD model mice. Howeve...
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doaj-60558c7456a14b508d754068e3a5ec1b2021-07-02T07:01:12ZengHindawi LimitedBehavioural Neurology0953-41801875-85842019-01-01201910.1155/2019/32485193248519Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in MiceHajime Shishido0Masaki Ueno1Kana Sato2Masahisa Matsumura3Yasunori Toyota4Yutaka Kirino5Takashi Tamiya6Nobuyuki Kawai7Yasushi Kishimoto8Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, JapanDepartment of Inflammation Pathology, Faculty of Medicine, Kagawa University, Takamatsu 761-8057, JapanLaboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, JapanLaboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, JapanDepartment of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, JapanLaboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, JapanDepartment of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, JapanKagawa General Rehabilitation Hospital, Takamatsu 761-8057, JapanLaboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, JapanThere has been growing awareness of the correlation between an episode of traumatic brain injury (TBI) and the development of Alzheimer’s disease (AD) later in life. It has been reported that TBI accelerated amyloid-β (Aβ) pathology and cognitive decline in the several lines of AD model mice. However, the short-term and long-term effects of TBI by the weight-drop method on amyloid-β pathology and cognitive performance are unclear in wild-type (WT) mice. Hence, we examined AD-related histopathological changes and cognitive impairment after TBI in wild-type C57BL6J mice. Five- to seven-month-old WT mice were subjected to either TBI by the weight-drop method or a sham treatment. Seven days after TBI, the WT mice exhibited significantly lower spatial learning than the sham-treated WT mice. However, 28 days after TBI, the cognitive impairment in the TBI-treated WT mice recovered. Correspondingly, while significant amyloid-β (Aβ) plaques and amyloid precursor protein (APP) accumulation were observed in the TBI-treated mouse hippocampus 7 days after TBI, the Aβ deposition was no longer apparent 28 days after TBI. Thus, TBI induced transient amyloid-β deposition and acute cognitive impairments in the WT mice. The present study suggests that the TBI could be a risk factor for acute cognitive impairment even when genetic and hereditary predispositions are not involved. The system might be useful for evaluating and developing a pharmacological treatment for the acute cognitive deficits.http://dx.doi.org/10.1155/2019/3248519 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hajime Shishido Masaki Ueno Kana Sato Masahisa Matsumura Yasunori Toyota Yutaka Kirino Takashi Tamiya Nobuyuki Kawai Yasushi Kishimoto |
spellingShingle |
Hajime Shishido Masaki Ueno Kana Sato Masahisa Matsumura Yasunori Toyota Yutaka Kirino Takashi Tamiya Nobuyuki Kawai Yasushi Kishimoto Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice Behavioural Neurology |
author_facet |
Hajime Shishido Masaki Ueno Kana Sato Masahisa Matsumura Yasunori Toyota Yutaka Kirino Takashi Tamiya Nobuyuki Kawai Yasushi Kishimoto |
author_sort |
Hajime Shishido |
title |
Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice |
title_short |
Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice |
title_full |
Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice |
title_fullStr |
Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice |
title_full_unstemmed |
Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice |
title_sort |
traumatic brain injury by weight-drop method causes transient amyloid-β deposition and acute cognitive deficits in mice |
publisher |
Hindawi Limited |
series |
Behavioural Neurology |
issn |
0953-4180 1875-8584 |
publishDate |
2019-01-01 |
description |
There has been growing awareness of the correlation between an episode of traumatic brain injury (TBI) and the development of Alzheimer’s disease (AD) later in life. It has been reported that TBI accelerated amyloid-β (Aβ) pathology and cognitive decline in the several lines of AD model mice. However, the short-term and long-term effects of TBI by the weight-drop method on amyloid-β pathology and cognitive performance are unclear in wild-type (WT) mice. Hence, we examined AD-related histopathological changes and cognitive impairment after TBI in wild-type C57BL6J mice. Five- to seven-month-old WT mice were subjected to either TBI by the weight-drop method or a sham treatment. Seven days after TBI, the WT mice exhibited significantly lower spatial learning than the sham-treated WT mice. However, 28 days after TBI, the cognitive impairment in the TBI-treated WT mice recovered. Correspondingly, while significant amyloid-β (Aβ) plaques and amyloid precursor protein (APP) accumulation were observed in the TBI-treated mouse hippocampus 7 days after TBI, the Aβ deposition was no longer apparent 28 days after TBI. Thus, TBI induced transient amyloid-β deposition and acute cognitive impairments in the WT mice. The present study suggests that the TBI could be a risk factor for acute cognitive impairment even when genetic and hereditary predispositions are not involved. The system might be useful for evaluating and developing a pharmacological treatment for the acute cognitive deficits. |
url |
http://dx.doi.org/10.1155/2019/3248519 |
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