Lipopolysaccharide Pre-conditioning Attenuates Pro-inflammatory Responses and Promotes Cytoprotective Effect in Differentiated PC12 Cell Lines via Pre-activation of Toll-Like Receptor-4 Signaling Pathway Leading to the Inhibition of Caspase-3/Nuclear Factor-κappa B Pathway

Lipopolysaccharide Pre-conditioning Attenuates Pro-inflammatory Responses and Promotes Cytoprotective Effect in Differentiated PC12 Cell Lines via Pre-activation of Toll-Like Receptor-4 Signaling Pathway Leading to the Inhibition of Caspase-3/Nuclear Factor-κappa B Pathway

Lipopolysacharide (LPS) pre-conditioning (PC), has been shown to exert protective effects against cytotoxic effects. Therefore, we hypothesized, the tolerance produced by LPS PC will be resulted by the alterations and modifications in gene and protein expression. With reference to the results of MTT...

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Bibliographic Details
Main Authors: Pushpa Gandi Sangaran, Zaridatul Aini Ibrahim, Zamri Chik, Zahurin Mohamed, Abolhassan Ahmadiani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neuroinflammation
Lipopolysaccharide
Toll-like Receptor 4
Pre-conditioning
cytoprotective
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.598453/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.598453/full

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