Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding

Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding

Development of medications selective for dopamine D2 or D3 receptors is an active area of research in numerous neuropsychiatric disorders including addiction and Parkinson’s disease. The positron emission tomography (PET) radiotracer [11C]-(+)-PHNO, an agonist that binds with high affinity to both D...

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Bibliographic Details
Main Authors: Kelly Smart, Jean-Dominique Gallezot, Nabeel Nabulsi, David Labaree, Ming-Qiang Zheng, Yiyun Huang, Richard E. Carson, Ansel T. Hillmer, Patrick D. Worhunsky
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:NeuroImage
Subjects:
Dopamine
D3 receptors
Positron emission tomography
Independent component analysis
Receptor occupancy
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920302494

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http://www.sciencedirect.com/science/article/pii/S1053811920302494

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