Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen

Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen

Pemphigus Vulgaris is an autoimmune disease of the skin and mucous membranes, which is due to the production of pathogenic autoantibodies targeting desmoglein (DSG) 1 and 3, which are adhesion proteins of the keratinocytes. Rituximab is an anti-CD20 mAb which induces a prolonged depletion of blood B...

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Bibliographic Details
Main Authors: Vivien Hébert, Marie Petit, Maud Maho-Vaillant, Marie-Laure Golinski, Gaëtan Riou, Céline Derambure, Olivier Boyer, Pascal Joly, Sébastien Calbo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
pemphigus
rituximab
corticosteriods
autoreactive B cell
transcriptomic analysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01794/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01794/full

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