Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.

Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.

Severe Plasmodium falciparum malaria is a major cause of global mortality, yet the immunological factors underlying progression to severe disease remain unclear. CD4(+)CD25(+) regulatory T cells (Treg cells) are associated with impaired T cell control of Plasmodium spp infection. We investigated the...

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Bibliographic Details
Main Authors: Gabriela Minigo, Tonia Woodberry, Kim A Piera, Ervi Salwati, Emiliana Tjitra, Enny Kenangalem, Ric N Price, Christian R Engwerda, Nicholas M Anstey, Magdalena Plebanski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2668192?pdf=render

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http://europepmc.org/articles/PMC2668192?pdf=render

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