Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells

Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells

Thymic blood vessels at the perivascular space (PVS) are the critical site for both homing of hematopoietic progenitor cells (HPCs) and egress of mature thymocytes. It has been intriguing how different opposite migrations can happen in the same place. A subset of specialized thymic portal endothelia...

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Bibliographic Details
Main Authors: Huan Xia, Suijuan Zhong, Yixiao Zhao, Boyang Ren, Zhongnan Wang, Yaoyao Shi, Qian Chai, Xiaoqun Wang, Mingzhao Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
thymus
thymocyte
cell migration
endothelial cell
lymphotoxin beta receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.707404/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.707404/full

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