Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge?

Targeted therapeutics underwent a revolution with the entry of monoclonal antibodies in the medical toolkit. Oligonucleotide aptamers form another family of target agents that have been lagging behind in reaching the clinical arena in spite of their potential clinical translation. Some of the reason...

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Bibliographic Details
Main Authors: Mayte Sola, Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Mario Martínez Soldevilla, Fernando Cartón-García, Fernando Pastor
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301517