Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking.

Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking.

The NS5B polymerase is one of the most attractive targets for developing new drugs to block Hepatitis C virus (HCV) infection. We describe the discovery of novel potent HCV NS5B polymerase inhibitors by employing a virtual screening (VS) approach, which is based on random forest (RB-VS), e-pharmacop...

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Bibliographic Details
Main Authors: Yu Wei, Jinlong Li, Jie Qing, Mingjie Huang, Ming Wu, Fenghua Gao, Dongmei Li, Zhangyong Hong, Lingbao Kong, Weiqiang Huang, Jianping Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4742222?pdf=render

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http://europepmc.org/articles/PMC4742222?pdf=render

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