Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study

Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Fragile X mental retardation protein (FMRP), a putative translation suppressor, is absent or significantly reduced in FXS. One prevailing hypothesis is that rates of protein synthesis are increased by the absence...

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Bibliographic Details
Main Authors: Kathleen C. Schmidt, Inna Loutaev, Zenaide Quezado, Carrie Sheeler, Carolyn Beebe Smith
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
Protein synthesis
Positron emission tomography
Translation
Sedation
Dexmedetomidine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302539

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http://www.sciencedirect.com/science/article/pii/S0969996120302539

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