Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

K-Ras is one of the most frequently mutated oncogenes in human tumor cells. It consists of a well-conserved globular catalytic domain and a flexible tail-like hypervariable region (HVR) at its C-terminal end. It plays a key role in signaling networks in proliferation, differentiation, and survival,...

Full description

Bibliographic Details
Main Authors: Balint Dudas, Franci Merzel, Hyunbum Jang, Ruth Nussinov, David Perahia, Erika Balog
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
K-Ras4B
KRas4B
autoinhibition
molecular dynamics
normal modes
conformational search
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00145/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00145/full

Similar Items