Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis

The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there is accumulating evidence in human epithelial cancer that BTB-ZF genes, such as Bcl6 and ZBTB7A, are oncogenic. From our previous studies in the vinegar fly, Drosophila mel...

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Bibliographic Details
Main Authors: Nezaket Turkel, Marta Portela, Carole Poon, Jason Li, Anthony M. Brumby, Helena E. Richardson
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Biology Open
Subjects:
Drosophila
Eye-antennal disc
Apico-basal cell polarity
Actin cytoskeletal regulators
BTB-ZF
Abrupt
RhoGEF2
Rac1
Src
Scribble
Online Access:http://bio.biologists.org/content/4/8/1024

Internet

http://bio.biologists.org/content/4/8/1024

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