Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen–Antioxidant Mutual Prodrugs

Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen–Antioxidant Mutual Prodrugs

Dexibuprofen–antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects. The esters analogs of dexibuprofen 5a–c were obtained by reacting its –COOH group with chloroacetyl derivatives 3a–c. The in vitro hydrolysis data confirmed that synthesized prodrugs 5a–c were s...

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Bibliographic Details
Main Authors: Zaman Ashraf, Alamgeer, Raqiqatur Rasool, Mubashir Hassan, Haseeb Ahsan, Samina Afzal, Khurram Afzal, Hongsik Cho, Song Ja Kim
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
nonsteroidal anti-inflammatory drugs (NSAIDs)
mutual prodrugs
dexibuprofen
antioxidants
in vitro hydrolysis
pharmacological activity
molecular dynamics simulation
Online Access:http://www.mdpi.com/1422-0067/17/12/2151

Internet

http://www.mdpi.com/1422-0067/17/12/2151

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