Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

Nonsense-mediated mRNA Decay (NMD) degrades mutant mRNAs containing premature termination codon (PTC-mRNAs). Here we evaluate the consequence of NMD activity in colorectal cancers (CRCs) showing microsatellite instability (MSI) whose progression is associated with the accumulation of PTC-mRNAs encod...

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Bibliographic Details
Main Authors: Jamila El-Bchiri, Agathe Guilloux, Peggy Dartigues, Etienne Loire, Dominique Mercier, Olivier Buhard, Iradj Sobhani, Pierre de la Grange, Didier Auboeuf, Françoise Praz, Jean-François Fléjou, Alex Duval
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2440797?pdf=render

Internet

http://europepmc.org/articles/PMC2440797?pdf=render

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