Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.
Nonsense-mediated mRNA Decay (NMD) degrades mutant mRNAs containing premature termination codon (PTC-mRNAs). Here we evaluate the consequence of NMD activity in colorectal cancers (CRCs) showing microsatellite instability (MSI) whose progression is associated with the accumulation of PTC-mRNAs encod...
Main Authors: | Jamila El-Bchiri, Agathe Guilloux, Peggy Dartigues, Etienne Loire, Dominique Mercier, Olivier Buhard, Iradj Sobhani, Pierre de la Grange, Didier Auboeuf, Françoise Praz, Jean-François Fléjou, Alex Duval |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-07-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2440797?pdf=render |
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