Reinstatement of Morphine-Induced Conditioned Place Preference in Mice by Priming Injections
To construct a model of relapse of drug abuse in mice, the induction, we evaluated the extinction and reinstatement of morphine-induced place preference. In Experiment 1, we examined the effects of morphine (0, 2, 3, 5, 10, 20 and 40 mg/kg) in the conditioned place preference (CPP) paradigm. Mice sh...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2003-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2003.279 |
| Summary: | To construct a model of relapse of drug
abuse in mice, the induction, we evaluated the
extinction and reinstatement of morphine-induced
place preference. In Experiment 1, we
examined the effects of morphine (0, 2, 3, 5, 10,
20 and 40 mg/kg) in the conditioned place
preference (CPP) paradigm. Mice showed CPP
with 5, 10, 20 and 40 mg/kg. In Experiment 2,
we evaluated the effects of two different extinction
procedures. After conditioning with 40
mg/kg of morphine, the mice underwent daily
extinction sessions of 60 or 15 min of duration.
CPP was extinguished after seven and nine
sessions, respectively. In Experiment 3, we
tested the reinstating effects of several priming
doses of morphine. Mice were conditioned with
40 mg/kg of morphine and underwent the daily
15 min extinction sessions until CPP was no
longer evident. Then, the effects of morphine (0,
2, 3, 5, 10, 20, 40 mg/kg, i.p.) were evaluated.
CPP was reinstated by doses from 5 mg/kg
upward. The results show that morphine priming
injections are effective in reactivating opiateseeking
behavior in mice, and thus, the CPP
paradigm might be useful to investigate the
mechanisms underlying relapse of drug abuse. |
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| ISSN: | 2090-5904 1687-5443 |