Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Abstract Tau is normally a highly soluble phosphoprotein found predominantly in neurons. Six different isoforms of tau are expressed in the adult human CNS. Under pathological conditions, phosphorylated tau aggregates are a defining feature of neurodegenerative disorders called tauopathies. Recent f...

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Bibliographic Details
Main Authors: Arthur Lionnet, Matthew A. Wade, Anne-Gaëlle Corbillé, Alice Prigent, Sébastien Paillusson, Maddalena Tasselli, Jacques Gonzales, Emilie Durieu, Malvyne Rolli-Derkinderen, Emmanuel Coron, Emilie Duchalais, Michel Neunlist, Michael S. Perkinton, Diane P. Hanger, Wendy Noble, Pascal Derkinderen
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Tau isoform
Tau phosphorylation
Enteric nervous system
Progressive supranuclear palsy
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s40478-018-0568-3

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http://link.springer.com/article/10.1186/s40478-018-0568-3

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