LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.

Bibliographic Details
Main Authors: Da-Hye Lee, Jae Oh Park, Tae-Shin Kim, Sang-Kyum Kim, Tack-hoon Kim, Min-chul Kim, Gun Soo Park, Jeong-Hwan Kim, Shinji Kuninaka, Eric N. Olson, Hideyuki Saya, Seon-Young Kim, Ho Lee, Dae-Sik Lim
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11961

Internet

https://doi.org/10.1038/ncomms11961

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