NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

Abstract Ferroptosis is an iron-dependent cell death characterized by the accumulation of hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging...

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Bibliographic Details
Main Authors: Can Huang, Patricia Santofimia-Castaño, Xi Liu, Yi Xia, Ling Peng, Célia Gotorbe, Jose Luis Neira, Daolin Tang, Jacques Pouyssegur, Juan Iovanna
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00662-2

Internet

https://doi.org/10.1038/s41420-021-00662-2

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