Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.

Bibliographic Details
Main Authors: Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, R. Bryan Bell, Zhifeng Gu, Gianpietro Dotti, Zhen Gu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22674-3

Internet

https://doi.org/10.1038/s41467-021-22674-3

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