Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.
Bibliographic Details
Main Authors: |
Hongjun Li,
Zejun Wang,
Zhaowei Chen,
Tianyuan Ci,
Guojun Chen,
Di Wen,
Ruoxin Li,
Jinqiang Wang,
Huan Meng,
R. Bryan Bell,
Zhifeng Gu,
Gianpietro Dotti,
Zhen Gu |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/s41467-021-22674-3
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